Mark Borja Faculty Profile
Mark Borja
Assistant Professor
Department of Chemistry & Biochemistry
- E-mail: mark.borja@csueastbay.edu
- Office: SC-S 450
The ability to change conformation (that is, change shape) is a key aspect in the function of many proteins. Apolipoprotein A-I (apoA-I) is the major protein responsible for the formation of high density lipoprotein (HDL, commonly known as the “good cholesterol”), and undergoes significant conformational change as it transitions between lipid-free and lipid-bound forms, as well as during the maturation of the HDL particle. My work focuses on understanding how apoA-I transitions between lipid-free and lipid-bound forms, how different types of lipids affect the interaction of apoA-I with the HDL particle, and how post-translational modification of apoA-I impacts its ability to undergo conformational change. The ability to transition between lipid-free and lipid-bound form has been shown to be relevant in the study of cardiovascular disease. Thus, our findings may shed light on the molecular mechanisms of this complex disease.
| Course # | Sec | Course Title | Days | From | To | Location | Campus |
|---|---|---|---|---|---|---|---|
| BIOL 490 | 04 | Independent Study | ARR | ARR | |||
| CHEM 112 | 01 | General Chem II | TTH | 9:30AM | 10:45AM | SC-N119 | |
| CHEM 112L | 1A | General Chem Lab II | TTH | 11:15AM | 1:45PM | SC-S437 | |
| CHEM 441 | 01 | Biochemistry I | MWF | 12:00PM | 1:10PM | SC-N320 | |
| CHEM 480 | 03 | Undergrad Research | ARR | ARR | |||
| CHEM 480 | 05 | Undergrad Research | ARR | ARR | |||
| CHEM 681 | 03 | Research | ARR | ARR |
Borja MS, Hammerson B, Tang C, Savinova OV, Shearer GC, Oda MN (2017) Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease. PLoS ONE 12(8): e0182217. doi: journal.pone.0182217
Heier M, Borja MS, Brunborg C, Seljeflot I, Margeirsdottir HD, Hanssen KF, Dahl-Jørgensen K, Oda MN (2017) Reduced HDL function in children and young adults with type 1 diabetes. Cardiovasc Diabetol. 16(1):85. doi: 10.1186/s12933-017-0570-2
Soupene E, Borja MS, Borda M, Larkin SK, Kuypers FA (2016) Featured Article: Alterations of lecithin cholesterol acyltransferase activity and apolipoprotein A-I functionality in human sickle blood. Exp. Biol. Med. 241(17):1933-1942. doi: 10.1177/1535370216657447
Borja MS, Ng KF, Irwin A, Hong J, Wu X, Isquith D, Zhao XQ, Prazen B, Gildengorin V, Oda MN, Vaisar T (2015) HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity. J Lipid Res. 56(10):2002-9. doi: 10.1194/jlr.M059865
Borja MS, Zhao L, Hammerson B, Tang C, Yang R, Carson N, et al. (2013) HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis. PLoS ONE 8(8): e71541. doi: 10.1371/journal.pone.0071541